Ali’s close friend, known for his quick temper and love for comics and drawing. Noodles struggles with his feelings toward his brother Needles and seeks to reconcile his resentment with the love he feels for him.

Noodles’s older brother who has Tourette’s syndrome, making him a reserved character who performs acts of kindness around his neighborhood. His condition challenges perceptions within the community and highlights his unique coping mechanisms.

Ali’s 11-year-old sister, known for her humor and her bantering relationships within the family. Her interactions with Ali help showcase his loving nature and sense of responsibility.

Ali and Jazz’s mother, a hardworking social worker who is a disciplinary yet loving presence. She educates Ali about Tourette’s syndrome and influences his approach to kindness and understanding.

Ali and Jazz’s father, a career thief known for his affectionate nature despite his absence from the home. His character evolves throughout the story, gradually becoming more dependable for his family.

A Vietnam veteran and mentor to Ali, Malloy trains boys in boxing and teaches valuable life lessons through his experiences. He provides guidance and support while dealing with his own personal challenges.

Known as a "jackass of all trades," Black is an entrepreneur in Ali's neighborhood with various talents. His lifestyle and work challenge Ali’s perceptions of hustler culture.

The mother of Noodles and Needles, who plays a minor role in the story. A single parent, she is portrayed as failing to support her children emotionally and physically, contributing to family tension.