The deuteragonist and founder of Lockwood & Co., known for his ability to see death-glows and his charismatic, daring nature. He leads the agency with a mix of humor, optimism, and strategic cunning in pursuit of solving supernatural mysteries.

An original member of Lockwood & Co., initially perceived as abrasive but vital for his research skills and attention to detail. His evolving role as an active participant in the team's ghost-hunting efforts highlights his growth and importance to the agency’s success.

The wealthy owner of Fairfax Iron, whose involvement with the agency marks him as a figure of intrigue. His eccentricity and initial intentions create tension as Lockwood & Co. navigate the challenges he presents.

A DEPRAC agent whose skeptical view of the youthful agency creates friction. He serves as both a critic and a reluctant ally, monitoring Lockwood & Co.'s activities with a mix of authority and begrudging respect.

A former lover of Annabel Ward, whose enigmatic presence and past connection to the haunting are sources of suspicion. His character adds layers of mystery to the unfolding investigation.