Death, another of the Endless, is a compassionate and wise figure who helps guide Dream through his journey and holds a close, supportive relationship with him.

Desire is one of the Endless known for scheming and undermining Dream; they view humans as creatures to control and manipulate.

Despair, one of the younger Endless siblings, plays a secondary role and represents feelings of hopelessness and melancholy within the series.

Destiny is an elder sibling among the Endless, committed to his role, and represents the inexorable fate that guides the universe.

Delirium is one of the younger Endless known for her whimsy and unpredictability, contrasting with her siblings' more serious tones.

Also known as "The Prodigal," Destruction is one of the younger Endless who has abandoned his role and is seen only briefly in the series.

Rose is an everyman character who finds herself embroiled in the dream world while searching for her missing brother, serving as a relatable anchor for readers.

Lucifer is a character inspired by the biblical figure, ruling Hell with a complex relationship with Dream, and is known for abandoning his role much like Destruction.

John Constantine is a rugged, streetwise character from the DC universe who encounters Dream early in his journey back into the human world, introducing him to new perspectives.