Sanford is a charismatic man drawn to high-society pleasures, known for his vanity and libertine lifestyle. He becomes entangled in Eliza's life with intentions that reveal his self-serving nature.

A recent university graduate aspiring to be a clergyman, Boyer offers stability and sincerity as a suitor to Eliza. His cautious nature contrasts sharply with his rival, Major Sanford, as he represents the societal ideal of honorable conduct.

Julia is a friend of Eliza with strong morals and a lively spirit, providing companionship while trying to sway Eliza from destructive choices. Her presence in the narrative offers a practical perspective on self-control and discretion.

Lucy's friendship with Eliza is central to the narrative, and she often advises Eliza on personal matters. Her marriage and subsequent move to Boston cause a distance that is mirrored by Eliza's mounting personal troubles.

A friend of Eliza and an embodiment of societal virtues, Mrs. Richman contrasts with Eliza's more carefree disposition. Her prudence reflects societal norms of successful womanhood in early American society.

Initially a target of Major Sanford, Nancy marries him, facing a challenging and loveless relationship. Her story demonstrates the personal costs of Sanford's manipulative ventures.

Eliza's caring mother, who supports her daughter while offering guidance based on strong moral principles. Her relationship with Eliza underscores the weight of familial bonds and expectations.

A close confidant of Reverend Boyer, Selby observes Eliza's social interactions and reports to Boyer, offering advice protective of Boyer's interests. His observations influence Boyer's decisions regarding Eliza.

A confidant of Major Sanford, Deighton receives letters revealing Sanford's inner thoughts and actions, though he himself remains absent from the narrative.