Caridad is the second youngest sister, known for her beauty. She marries her high school sweetheart, suffers from his infidelity, and deals with personal trauma, eventually gaining powers of prediction and becoming a curandera under doña Felicia.

La Loca is the youngest of Sofi’s daughters, who dies at age three but is resurrected at her funeral. She has healing powers and avoids society, spending her life in her mother's house due to repulsion from human touch.

Fe is the second youngest sister who works at a bank and dreams of a normal life. After her engagement ends, she endures a breakdown and later marries her cousin Casey. She works at a factory, suffers health issues from toxic exposure, and dies young from cancer.

Esperanza is the eldest sister, who is spirited and academically successful. She becomes a journalist and war correspondent. Her career leads her to Saudi Arabia, where she goes missing and is assumed dead, although she returns in a spiritual form.

Doña Felicia is the town’s curandera and an independent woman who helps Caridad learn healing practices. She embodies cultural blending, balancing folk healing with Catholicism.

Domingo is Sofi’s husband, notorious for his gambling habits which cause financial and emotional strain on his family. He leaves and returns after twenty years but is eventually divorced by Sofi.

Francisco is Doña Felicia’s godson, a Vietnam veteran turned santero and penitente. He becomes obsessed with Caridad after discovering her in a cave and participates in religious and cultural traditions.