A highly intelligent and charismatic inmate at Baltimore State Hospital for the Criminally Insane, known for his past as a psychiatrist and his involvement in a series of murders.

The experienced Section Chief of the FBI Behavioral Sciences Unit who mentors Clarice during her investigation, balancing personal and professional pressures.

The elusive and intelligent serial killer targeted by the FBI, known for his disturbing crimes and complex personal history.

The ambitious and self-important head administrator of Baltimore State Hospital for the Criminally Insane, who often antagonizes Clarice and Lecter.

Clarice's supportive roommate and confidant at the FBI Academy, providing emotional support and understanding throughout their training.

An orderly at the Baltimore State Hospital for the Criminally Insane, recognized for his compassionate and respectful treatment of inmates.

The daughter of a senator and a substantial focus of the investigation as a victim of Buffalo Bill, demonstrating determination and resourcefulness.

The devoted mother of Catherine, using her political influence to aid the investigation while handling the pressure of public scrutiny.

Smithsonian entomologists who assist in identifying crucial evidence related to the investigation, with Pilcher being of personal interest to Clarice.

A Deputy Assistant Attorney General who poses bureaucratic challenges for Clarice during the investigation, representing a critical facet of investigative politics.

A doctor at the Johns Hopkins Gender Identity Clinic who prioritizes patient confidentiality and advocates for the sensitivities surrounding marginalized communities.