Art3mis is a well-known avatar in the OASIS, recognized for her popular blog and competitive nature. She shares an interest in solving the world's problems and often interacts with Wade in both competitive and personal ways.

Aech is Wade's best friend and a skilled combatant in the OASIS, known for a private chat room called The Basement. In real life, Aech is revealed to be Helen Harris, and the friendship remains strong despite differences between online and real-life identities.

Shoto is a young Japanese avatar who teams up with his counterpart, Daito, and later becomes closely involved with Wade. He sports samurai armor in the OASIS and shares a bond with Daito that resembles brotherhood.

Daito is Shoto's partner, showcasing loyalty and bravery within the OASIS through his samurai-themed avatar. Although he values privacy, Daito's actions often protect and support those around him.

Sorrento is the leader of a hostile faction known as the Sixers, with a professional background in game design. He is depicted as being ambitious and ruthless in his pursuit of control over the OASIS.

Ogden Morrow was the co-creator of the OASIS along with Halliday and serves as a protective ally to the story's main characters. He is distinguished by his eccentric appearance and long-standing friendship with Halliday.

James Halliday is the late creator of the OASIS, whose passing sets the stage for the contest within the virtual universe. His avatar, Anorak, is characterized by wizard-like robes, and throughout the narrative, he is a posthumous influence on the characters.

Aunt Alice is Wade's caretaker after his mother's death, described as having ulterior motives for taking him in. Her difficult circumstances are depicted through her struggles with addiction.