Ramona’s older sister who attends the same school, portrayed as sometimes unsupportive and annoyed by Ramona’s antics; she is friends with Henry Huggins.

Ramona’s patient yet stern mother, who consistently appears throughout the story and shows understanding and support for Ramona's growth and development.

Ramona’s admired kindergarten teacher, whom she seeks to please, and plays a central role in Ramona's school experiences, particularly related to behavior and impulse control.

Ramona’s neighbor and classmate, characterized by his lack of excitement and maturity in certain situations, often clashing with Ramona’s energetic personality.

A traffic boy at Ramona’s school and a friend of Beezus, who is reluctant but helpful in rescuing Ramona from various minor predicaments.