Beezus Quimby is Ramona’s older sister, who often feels both protective and annoyed by Ramona’s antics. Throughout the story, her relationship with Ramona evolves, highlighting the dynamic nature of their sisterly bond.

Mrs. Quimby is the patient and supportive mother of Beezus and Ramona, working at a doctor’s office while also providing emotional stability at home. She navigates challenges with optimism and remains a comforting presence in the family.

Mr. Quimby is the kind and humorous father of Beezus and Ramona, who balances his responsibilities at home while studying to become an art teacher. His understanding and supportive nature provide a strong paternal influence in the story.

Aunt Bea is Mrs. Quimby’s sister, who forms a close bond with her nieces, Ramona and Beezus. As a third-grade teacher, she effectively connects with children and brings joy to family gatherings.

Uncle Hobart is Howie Kemp’s uncle, who becomes Beezus and Ramona’s uncle as well. Initially cast as an antagonist, his relationship with Ramona evolves, highlighting his growth into a supportive family member.