An elderly woman suffering from severe asthma, who balances her family's dire needs with her husband's unyielding pride. She is practical and resilient, often taking care of household duties despite her illness.

A married couple expecting a baby, where Ana works as a laundress and seamstress while Damaso struggles with making poor choices to support them. Ana is forgiving and realistic, trying to manage their household while Damaso learns the consequences of his actions.

A 94-year-old priest whose unusual sermons have earned him some skepticism from his congregation. His discussions of apocalyptic visions bring attention back to his parish after a period of dwindling interest.

A legendary figure known as the "absolute sovereign of the Kingdom of Macondo," who maintains her influence through traditional and sometimes clandestine means. She is a pivotal character whose legacy is marked by both her power and her lack of direct heirs.