Harlen Bigbear is Will's optimistic best friend in Medicine River, who convinces him to move back home. He is known for being involved in everyone's lives and is considered a central figure in maintaining the community's cohesiveness.

Rose Sampson is Will and James's deceased mother, a Blackfoot woman who faced banishment for marrying a white man. Her resilience and devotion to her sons are evident through Will's memories of her.

Louise Heavyman is a local woman whom Will supports during her pregnancy. She is described as kind yet formidable and maintains a close but non-committed relationship with Will.

James Sampson is Will's brother, remembered mostly for his artistic talent and their shared childhood experiences. Unlike Will, James travels the world, and his character serves as a catalyst for Will’s personal growth.

David Plume is a local man known for his arrogance and violent tendencies. He is a veteran of the Wounded Knee occupation and remains active in protesting governmental policies toward Indigenous peoples.