Zeb is a resilient and mysterious leader with a complex past, known for his humor and bravery, having lived with the God's Gardeners and later assuming a role of leadership among the survivors.

Ren is a caring and talented trapeze dancer and sex worker who grew up in both the compounds and with the God's Gardeners, maintaining a strong bond with her friend Amanda.

Amanda is a strong and protective pleebrat who lived with the God's Gardeners and experiences significant trauma but remains a steadfast friend to Ren.

Jimmy is the protagonist from the first book and plays a crucial but often unconscious role, known for surviving due to his friendship with Crake and taking on the responsibility of caring for the Crakers.

Blackbeard is a young and inquisitive Craker who learns to write from Toby and becomes a bridge between Crakers and humans, eventually taking over the role of storyteller.

Swift Fox is a confident and attractive former geneticist whose bold personality and interactions with Zeb and others adds to the group's dynamics.

Adam is the founder of the God's Gardeners, known for his wisdom and leadership, with a mysterious and protective relationship with Zeb.

Katrina Wu is connected to the sex work industry and is a significant figure for Adam, being the founder of Scales and Tails.

The Rev is the abusive father figure to Adam and Zeb, known for his role as a corrupt preacher and leader of the Church of PetrOleum.

Rebecca is known for her culinary skills with the God's Gardeners and the survivors, having served as both a protector and provider.

Lotis Blue, also known as Wakulla Price, is a supportive member of the MaddAddamites with connections to Jimmy's past and is known for her friendship with Ren and Amanda.

Crake is an influential figure who, though deceased, remains central to the plot for creating the Crakers and the events leading up to the survivors' situation.

Oryx is a mysterious figure linked to Crake and Jimmy and holds an iconic status among the Crakers as a part of their creation mythology.

Ivory Bill is a MaddAddamite characterized by his intellectual discussions on genetics and environment, and his interactions with other survivors.