Effia's story begins around 1762 in a Fante village. Daughter of Cobbe Otcher and Maame, she is raised by Baaba and eventually marries an Englishman, James Collins. Her life changes as she navigates relationships and her family's legacy, becoming a mother and grandmother in the narrative.

Esi is born into the Asante tribe after Effia. As a child, she unintentionally aids in her village's downfall and is captured and enslaved. Her story includes her experiences as a slave and her daughter Ness, as Esi grapples with separation and trauma.

Son of Effia and James Collins, Quey grows up around Cape Castle. He struggles with his mixed identity and the pressures of joining the slave trade. He experiences confusion regarding his African roots, his sexuality, and his role as a successor in his family's business.

Born into slavery around 1786, Ness is Esi's daughter. Her experiences in captivity are harsh, leading her to develop a stoic demeanor. Ness’s life is marked by trauma and loss, impacting her relationship with her son Kojo, whom she loves dearly.

Grandson of Effia, James is born to Quey Collins and Nana Yaa around 1807. He faces family pressures related to the slave trade but seeks a different path, prioritizing an honorable life despite hardships, and later passes the family necklace to Abena.

Daughter of Abena and Ohene Nyarko, Akua grows up in the Christian missionary school. Her life is marked by supernatural dreams and mental health struggles. Through her dreams, she gains access to family history, ultimately becoming a figure who bridges past and present.

Born in Pratt City, Alabama, to H and Ethe, Willie has a notable singing talent but struggles with societal limitations. Her life's journey includes overcoming personal challenges, focusing on family, and becoming a matriarchal figure who keeps the family history alive.

Born to Akua Collins and Asamoah around 1900, Yaw becomes an intellectual and educator, emphasizing the importance of history. He overcomes family estrangement, marries Esther, and maintains a significant relationship with his mother, passing family knowledge to his daughter, Marjorie.

Son of Robert and Willie, Sonny grows up in Harlem. He channels his anger into civil rights activism but struggles with addiction. Through family support, he becomes a responsible father to Marcus, teaching him about the Black experience and family history.

Daughter of Yaw and Esther, born around 1969. She navigates her identity as an African living in Alabama and embraces her heritage. Her relationship with Akua is significant, and she later guides Marcus, representing the reunion of the family's separated lines.

Son of Sonny and Amani, Marcus grows up under the care of Willie and Sonny. He faces generational trauma and eventually finds healing through his friendship with Marjorie. Marcus's journey includes understanding systemic oppression and reconciling with his ancestry.