Beezus, whose real name is Beatrice, is a responsible and supportive friend to Henry as well as the older sister of Ramona, often keeping things in order and helping with Henry’s plans.

Ramona is Beezus's energetic and imaginative younger sister, known for her playful antics and humorous demands that often amuse yet exasperate those around her.

Ribsy is Henry's mischievous and loyal dog who often gets into trouble, but remains a valued companion to Henry throughout various adventures.

Scooter is an older boy in the neighborhood, admired yet envied by Henry for his bicycle and independence, and serves as Henry’s friendly albeit competitive rival.