The eldest Sackler brother who became a doctor and was involved in medical advertising. His career was marked by avoiding regulation and ethical conflicts, and he ultimately amassed significant wealth and an art collection.

Arthur's younger brother who developed Purdue's foreign subsidiaries and lived a lavish lifestyle. He was later involved in the opioid market through MS Contin.

The youngest Sackler brother who helped build Purdue Frederick and oversaw the launch of MS Contin. He remained deeply involved in the company and maintained a culture of denial regarding its controversies.

Arthur Sackler's second wife, a German doctor, who provided personal insights into Arthur's complex personality through her unpublished memoirs.

Arthur Sackler's third wife who was active in his artistic and philanthropic pursuits. After his death, she sought to distance him from the family's scandals related to OxyContin.

Raymond Sackler's eldest son who played a leading role at Purdue. He was heavily involved in the development and promotion of OxyContin.

Mortimer's daughter who worked at Purdue and claimed partial credit for the idea of OxyContin but distanced herself from its controversies.

An investigative journalist with The New York Times who reported on OxyContin's addictive nature and faced pressure from Purdue as a result.

Purdue's devoted company lawyer who played a key role in launching MS Contin and later faced legal consequences for the company's actions.

A photographer and activist who, driven by personal experiences with addiction, campaigned against the Sacklers' influence in the art world.

Richard Sackler's son and the third-generation family member to work at Purdue. He attempted to rehabilitate the family's image amid legal troubles.

A filmmaker and Richard Sackler's granddaughter, who focused on social issues in her work but avoided discussing her family's impact on such issues.

Mortimer's son from his second marriage, who focused on maintaining a luxurious lifestyle and sought influential support during family legal troubles.

Former attorney general of Massachusetts who pursued legal action against Purdue, seeking accountability for their role in the opioid crisis.

David Sackler's wife, who became a fashion influencer and launched a clothing line. She distanced her work from Purdue's controversies.

Father of the Sackler brothers, who initially ran a grocery business and acquired real estate. He impressed upon his sons the importance of a "good name."

A business associate of the Sackler brothers who ran a supposedly rival ad agency that Arthur Sackler secretly co-owned.

A doctor who worked closely with Arthur Sackler and was involved in the intersection of Pfizer and the FDA during their early collaborations.

Head of the FDA's antibiotics division in the 1950s who had a conflict of interest due to his partnership with Arthur Sackler.

A Democratic senator known for investigating crime and corruption, including the pharmaceutical industry's ties to the FDA.