The book centers on James A. Garfield, detailing his presidency and assassination. He rose from humble beginnings in Ohio to become a significant political figure and was later elected President of the United States.

Charles Guiteau is known for assassinating President James A. Garfield. His life was marked by instability and delusion, leading to his desperate act when he felt slighted by Garfield.

Dr. Bliss was the primary physician overseeing President Garfield's care after he was shot. Known for his past involvement in trying to save President Lincoln, his medical practices and decisions were pivotal in the events surrounding Garfield’s treatment.

Inventor of the telephone, Alexander Graham Bell attempted to aid in locating the bullet in President Garfield with a device based on electrical induction. His involvement brought an intersection of innovation and medical urgency.

Joseph Lister was a pioneering English surgeon who introduced antiseptic techniques. His theories on germs and sterilization were not fully adopted in the United States during the time of Garfield’s treatment.

Chester Arthur became President following Garfield's death. Initially elected as Vice President, he was associated with the Stalwarts and later played a role in civil service reform during his presidency.

An influential senator from New York, Roscoe Conkling was a political rival of President Garfield. He was known for his staunch support of the political patronage system, which Garfield opposed.

James Garfield and his wife, Lucretia, had seven children, with five surviving to adulthood. The family faced personal tragedy both before and after Garfield's presidency.