Demon's neighbors and substitute parents in his youth. They provide support but can't save him from himself, limited by their age and health.

Demon's lifelong best friend who also faces his own challenges, including loneliness and a meth addiction, before eventually turning his life around.

Demon's abusive stepfather who contributes to the turmoil in Demon’s life, misleading Demon’s mother before showing his true, harmful nature.

Demon’s first foster home guardian who exemplifies the flaws in the foster care system by exploiting children for labor on his farm.

A stable and supportive friend of Demon who encourages him to engage with his culture’s history and identity, helping him explore comic publishing.

An idol for Demon in foster care, initially seen as charismatic and successful but ultimately leading a destructive path involving drugs and manipulation.

Maggot’s cousin and a childhood friend of Demon’s. She faces significant challenges, including addiction, but is eventually helped by Aunt June.

Maggot's aunt and Emmy's adopted mother, a nurse dedicated to combating the opioid epidemic, who aids Demon in his recovery journey.

Demon’s second foster care placement. A large, poor family, contributing to Demon’s hardships through neglect and illustrating systemic poverty.

Demon’s social worker, who is overwhelmed by her workload and unable to attend fully to Demon’s needs, representing shortcomings in the social work system.

Demon’s paternal grandmother, who offers some support but is unwilling to fully take him in, contributing to his sense of isolation.

Betsy’s brother, who, despite his infirmities, is a kind, happy man and a voracious reader. He plays a minor supportive role in Demon’s life.

Demon’s unofficial foster sister, a strong and intelligent presence who later shows unconditional love towards Demon and aspires to become a social worker.

Demon’s unofficial foster parent and high school football coach, who assists Demon but struggles with his own personal challenges, including a drinking problem.

An antagonist who exploits Coach Winfield's trust and positions himself to embezzle money and exhibit predatory behavior toward Angus.

Demon’s first significant girlfriend who introduces him to harder drugs, playing a cautionary role regarding addiction and emotional dependence.

Maggot’s cousin and Emmy’s former boyfriend, who is well-intentioned and proud until his efforts to help lead to tragic consequences.