Dennis is Arnie's best friend who narrates parts of the story and takes on a heroic role in an attempt to save Arnie.

LeBay is the former owner of Christine and the novel's primary antagonist, closely linked with the car's malevolent influence.

Leigh is Arnie's romantic interest who notices Christine's negative impact on Arnie and becomes an ally in confronting the car's dark influence.

Darnell owns the garage where Arnie keeps Christine and becomes an antagonist due to his criminal dealings and connection to the car.

Arnie's family consists of his upper-middle-class parents, whose relationship with him becomes strained as he becomes more obsessed with Christine.

Buddy is a bully in Arnie's school who, with his group of friends, becomes one of the story's antagonistic forces.

George is Rollie LeBay's younger brother who warns Arnie of the danger posed by Christine and his brother's malevolent past.

Junkins is a state detective investigating the events surrounding Arnie and Christine, adding tension to the unfolding narrative.