The active protagonist of Bone, she is a farmgirl who embarks on a journey to discover the truth of her origins and fulfill her destiny. Over time, she evolves from a civilian to a warrior, and ultimately to a queen with deep connections to the spirit world.

Fone's cousin and a deuteragonist known for his greed and mischievousness, often causing trouble with his schemes. Despite his flaws, he plays a crucial role in both inciting and resolving the story's events.

A formidable antagonist who serves as the sorceress and intermediary for the overarching evil in Bone. Her sinister presence is enhanced by her mysterious identity and powerful magic.

Recurring comic antagonists depicted as bumbling, inept henchmen who contribute to Bone's humor. They often engage in humorous antics while also posing a legitimate threat at times.