Beezus’s younger sister, whose antics and unique view of the world create both humorous and challenging situations for the family. Ramona’s actions provide opportunities for Beezus to mature and better understand family relationships.

Beezus’s admired aunt, who represents independence and wisdom. Although she makes a late appearance, Aunt Beatrice is a significant influence on Beezus, serving as a role model and offering support and encouragement.

The mother of Beezus and Ramona, who manages household duties and grapples with the demands of family life. Through the story, she transforms in Beezus's eyes from a harried mother to a more relatable and sympathetic figure.

The father of Beezus and Ramona, who plays a minimal role in the narrative. His character is defined by his traditional paternal presence and lack of involvement in the daily challenges faced by the family.